Fix issues with some models failing to find steady state. - #1356
Merged
Conversation
Made some changes, but need to make sure they don't break things elsewhere.
We were dropping all rule-defined species from the conserved moiety test, but those with rate rules needed to not be dropped, and instead not look for conserved moieties.
Tracked down the problem to conflicted AssignmentRules when we suddenly allowed species with assignment rules to participate in conserved moiety analysis runs.
This file contains hidden or bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment
Add this suggestion to a batch that can be applied as a single commit.This suggestion is invalid because no changes were made to the code.Suggestions cannot be applied while the pull request is closed.Suggestions cannot be applied while viewing a subset of changes.Only one suggestion per line can be applied in a batch.Add this suggestion to a batch that can be applied as a single commit.Applying suggestions on deleted lines is not supported.You must change the existing code in this line in order to create a valid suggestion.Outdated suggestions cannot be applied.This suggestion has been applied or marked resolved.Suggestions cannot be applied from pending reviews.Suggestions cannot be applied on multi-line comments.Suggestions cannot be applied while the pull request is queued to merge.Suggestion cannot be applied right now. Please check back later.
Fix for #1350, roadrunner failing to find the steady state for BioModel 64. Turned out to have two parts: some species were 'constant' but not 'boundary', and ended up in the 'floating species' section, making parts of the stoichiometry matrix all zeroes. Also, since there were assignment rules, roadrunner didn't want to find conserved moieties, so the NAD+NADH conserved cycle created other problems in the Jacobian. Once we relaxed that restriction, it turned out that assignment rules affecting species levels wasn't being propagated. Fixing that finally made everything work!