diff --git a/bottleneck/src/bottleneck.h b/bottleneck/src/bottleneck.h
index 311facd76..371fefe99 100644
--- a/bottleneck/src/bottleneck.h
+++ b/bottleneck/src/bottleneck.h
@@ -4,7 +4,6 @@
 #define BOTTLENECK_H_
 
 #include <Python.h>
-#define NPY_NO_DEPRECATED_API NPY_1_11_API_VERSION
 #include <numpy/arrayobject.h>
 #include <bn_config.h>
 
diff --git a/pyproject.toml b/pyproject.toml
index 8f0d99154..5b53998ae 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -50,7 +50,10 @@ classifiers = [
     "Topic :: Scientific/Engineering",
 ]
 requires-python = ">=3.10"
-dependencies = ["numpy>=1.21.3"]
+dependencies = [
+    # keep in sync with NPY_* macros (setup.py)
+    "numpy>=1.21.3",
+]
 dynamic = ["version"]
 
 [project.urls]
diff --git a/setup.py b/setup.py
index 66bb9a6ab..a4b230f69 100644
--- a/setup.py
+++ b/setup.py
@@ -11,6 +11,11 @@
 
 import versioneer
 
+define_macros = [
+    # keep in sync with runtime requirements (pyproject.toml)
+    ("NPY_NO_DEPRECATED_API", "NPY_1_21_API_VERSION"),
+]
+
 
 class config(_config):
     def run(self):
@@ -109,6 +114,7 @@ def prepare_modules():
             "bottleneck.reduce",
             sources=["bottleneck/src/reduce.c"],
             depends=base_includes,
+            define_macros=define_macros,
             extra_compile_args=["-O2"],
         )
     ]
@@ -120,6 +126,7 @@ def prepare_modules():
                 "bottleneck/src/move_median/move_median.c",
             ],
             depends=base_includes + ["bottleneck/src/move_median/move_median.h"],
+            define_macros=define_macros,
             extra_compile_args=["-O2"],
         )
     ]
@@ -128,6 +135,7 @@ def prepare_modules():
             "bottleneck.nonreduce",
             sources=["bottleneck/src/nonreduce.c"],
             depends=base_includes,
+            define_macros=define_macros,
             extra_compile_args=["-O2"],
         )
     ]