Hello, cooler is a very convenient tool for 3D genome research. I encountered the following problem. Can you help me analyze the problem?
I used hicpro to get validpairs, only took cis pets and removed chrY and chrM. After using hicpro to build the matrix, I used hicConvertFormat to convert it to cool format. When I balanced, I kept getting the error:
ERROR: cooler.cli.balance: Iteration limit reached without convergence
ERROR: cooler.cli.balance: Storing final result. Check log to assess convergence.
I tried to set --cis-only and the number of convergences, but none of them worked. I don't know which step is problematic.
Thank you！
Hello, cooler is a very convenient tool for 3D genome research. I encountered the following problem. Can you help me analyze the problem?
I used hicpro to get validpairs, only took cis pets and removed chrY and chrM. After using hicpro to build the matrix, I used hicConvertFormat to convert it to cool format. When I balanced, I kept getting the error:
ERROR: cooler.cli.balance: Iteration limit reached without convergence
ERROR: cooler.cli.balance: Storing final result. Check log to assess convergence.
I tried to set --cis-only and the number of convergences, but none of them worked. I don't know which step is problematic.
Thank you！