diff --git a/README.md b/README.md
index f75ed154a..3faba77e0 100644
--- a/README.md
+++ b/README.md
@@ -392,6 +392,7 @@ The earth sciences folder contain subfolders for different data formats encounte
     - genome.fasta.gz.gzi: index file for 'genome.fasta.gz'
     - genome2.fasta: Reference fasta based on chr22:16600000-16800000
     - genome3.fasta: Reference fasta based on chr19:45760000-45770300
+    - genome3.fna: Reference fasta based on chr19:45760000-45770300 (copy of genome3.fasta, with different extension)
     - genomeGRCh38_chr21_22.fa.gz: bgzipped version of GRCh38 fasta file containing whole chr21 and chr22
     - genomeGRCh38_chr21_22.fa.gz.fai: index file for 'genomeGRCh38_chr21_22.fa.gz'
     - genomeGRCh38_chr21_22.fa.gz.gzi: index file for 'genomeGRCh38_chr21_22.fa.gz'
diff --git a/data/genomics/homo_sapiens/genome/genome3.fna b/data/genomics/homo_sapiens/genome/genome3.fna
new file mode 100644
index 000000000..e8b417360
--- /dev/null
+++ b/data/genomics/homo_sapiens/genome/genome3.fna
@@ -0,0 +1,208 @@
+>chr19:45760000-45770300
+catgttggccaggctggtctccaactcctgacctcgagtgatccgcccac
+cttggcctcctagagtgctgggattacaggtgtgagccaccgtgcccagc
+Ttcccacatcattttacaactactctacgaagcagggtctcctgtggccc
+cattttacagataaggaaattgaaatcaaaagactaagctgggcgcggtg
+gctcacacctgtaatctcagcagtttgagaggctgacgtaggcggatcac
+ctgagatcaggagttcaagaccagcctggccaacatggggaaaccccatt
+tctactaaaaatacaagaaGTGTccgggcgtggtggctcacgcctgtaat
+cccactattttgggaggccgaggagggcagatcacctgaggtcaggagtt
+ggagaccaaccagtctggccatcatggcgaaatactatctctactaaaaa
+tacaaaattagccgggtgtggtggtacgtgcctgtaatcccagctactca
+ggaggctgaggcagaagaatcgcttaaacctgggaggcgggggttgcagt
+aagccaagatggcaccgttggactgcagcctgggcaacaagagcgaaacc
+cagtctcaaaaaaggaaaagaaaaagaaaaagaaaTTATCAGGGTGTggc
+cgggcgtggtggctcatgcctatacttctagcactttgggaggctgaggc
+gggcagatcacctgaggtcaggagtttaaacctagcttgaccaatatgat
+gaaaccccctctctactaaaaatacaaaattagctgggcgtggtggtggg
+cacttgtaaccccagttactcaggagtctgaggcaggagaatcacttgaa
+cccaagaggtggagaatggagctgagatggtgccattgcactccagcctg
+agggacaagagtaagactccgtctcaaaaaaaaaaaaaagaaagaaaaga
+aaaaaaagaaaagaaaggaagaaagaaagaaagacagggtcttgctttgt
+tgcccaggctggagtgcagtgtcaccatcatagatcagtgccttgaactc
+ctgggctcaaatgaccctcccacaccaccatgcccagctggttttttaaa
+ttatttttaaatttaacttaattcaatttctttttttttttttgagacag
+agtctcactctgtcacccaggctggagtgcagtggtacgatctcggctca
+ctgcaacctccgcctcctggatttaagcgattcttgtgcctcagcctcca
+gagtagctgggactacaggcgcccaccaacatacctggctaattttttag
+tatttttagacagagtttcgccatgttggccaggctggttttgaactcct
+gacctcaggtgatcctcctgcctcagcctccgaaagtgctgagattacag
+gcatgagccactgcgcctggccTAtttttttttttttttttttttttttt
+ttgtagaacaaggtctctctatgttgcccaggctggtctgtaactcctgg
+cctcaagcagtcctcctgcctcagcctcccagagtgttggggttacaggc
+gtaagccaccacaccctgccAATCTGAGCTGCTGCTAATGCTCATGTTAT
+GTCCTAGAAAAGCAGTACTGGGGGGATGAAGGGGCACCACTTGTCTCCCC
+TCCCATCTTTCTCCCTCATCATGCCCCAGGACACAGCCTCCAAGGCCCCC
+AAAGACCCTCCTGAGTCCCACAGCCTGCACCGGTCCTCAGTCTCGCTGGA
+CCACTGCTACCTCTCGCTGAGCGGGAACAGCAAGGCGCCAtccagctcca
+gctccagctccagctccagctccagctcGGAGGACAGCGACTCGGAGCCC
+CTGTGGAAGCAGCGAGAGGTGAGAGACACGGCCGCATGCCAGGGCCAGCA
+GGGCCTCCTTCCTCTCTCACCACCCTCTCCCTCCCCCAGGATATGCAGGC
+CAACCCTGTGGGCACGCCGGGCTCCAGCGAAGAGGACGAAGACACCACAT
+GGACCCCCACCCGGCTGGCCTCACCCCTGCTGGCAGCTGAGAAAAAGGCC
+ACGAAGGGCCAAGTAGCCAGGGCCCCTGTGAAGCCCAAGGAGAAGAAGAA
+AGGCCCCTGCCCACCCCAGATGAAGAAGAAGTGTGTCAACGGCTTCATCA
+TGTTCTGCAGGATGAACCGGAAGCAGTACATCCGGTGGGTAGGGGGTCGT
+CTTTGGCCCTGGGGAAGGCCCTGGCTTCGTTCTCTGCCCGCAGCCTGGCC
+ATGCCGCTCCTCACAACTGTCTGACACTTTTTCCCCCTCCGAGACCCCAC
+AAACCCTTCGTGGACCACAGTTCTTCCCCAGAACTGAACCCGGCCCCATt
+gtattggacagggtccatccattgtcagcgctgaaacccaattcaggctt
+tagacttcagaaaaaaaggagttttttttgttttgttttgttttttgaga
+cagagtctcactctattgcccaggctgtagtgcagtggcacaatcacagc
+tcactgcaatgtctgcctcccgggctcaaatcactgcaacctctgcctct
+cagattctcctgcctcagcctcctgagtagctgggataacaggcgcgcca
+tcagctaatttttgtatttttagtagagacagggtttcaccatgttggcc
+aggctggtctcgaatgcctcacctcaagtgatctgcctgcctcggcctct
+caaattgctgggattacaggtgtgagccatcaggcccagcaagaaaagaa
+aatgaattggcttatataacctagaaaacaagggcgggtatagactgcct
+tgagacatagctggttttagggctcacacaggctgtctggaatctttgtc
+cttttcacccagttcctctgtcttccgggctggcttcattctctggcagg
+tggggtcaccccaggaggcacaggctcgggtcctgtcccccacccaagcg
+accccgggaggaggagaggtctctaaggttttaagcaaagtccttgggac
+tgactttggtagatccggtgccaaccctgaaccagtcactgccaggCCTG
+GAGCCAGGGGATGGGGAGGCCCCCCCCAAGCCACAGTGGAAAACAGCTAG
+TTCCTTTACAGGAAGATCCAGATGTGGGGGCCAGGAGCGGTGCCCACAGG
+TCCCCTGCACTCTCCTGGGACACCAGGTGCCCCCTTGTGAACAGCCGCTG
+AGTCCAGCTCCCTCTGCCTCCTCAGCTCCAGAGGGTGGTCTTGGAGGCCT
+TGTAGACCCACAAGGCTAGGAAGGGTCTGAGTTCTCAGTCAGGGTGTCCT
+GCAGACCTCTCCTTACCTCCTCCTCCTTCCTGTCCCAGATCCTGCCCTGG
+AACCGCTTCCACAGCTGCCACCAAGGAGCTGGCCCAGCTGTGGCGGGTGA
+TGACCCAGCAGGAGCGGAGGCCATACTGGTGAGAGGCTCCGGCCCCGAGG
+TGTGGGTGGGGGGTGGAAGAGCCTCCCTACCCCGGAACCCTGCTCTGTCT
+CTGGAGCCTTGGGTGTCATGGCATGGGAGACTGGGCCGAGGAATTTGCGT
+GTTGCCCCTTCTTATGAAACCCTTGGGGGTGACACAGGTGTAGGGGTACC
+CCACCACAGCTAAGCTGGGGAACAGCTGAGCCCAGACATGGACCCCTGCC
+TCAATTCTTTTGCTGTCTCTGCCACACGACTTTCTCGGGGCGTGGTCTGA
+TTTTCCTGTCGCTTGGCCACCTCGACTCCCCCGAATCCTGTCCCCTCCAC
+CTTCAAGGAGCTGCCACCTGCCCTGGCTCCTGACTTTGAACACATCCCAG
+AGCCCTTGGCCGAGTCCCATCTTACTGACTGGGACTTGGTGGACCCAAGG
+CTCGCCCAATAGAGGCTAAAACGGTGGCCCAGGCCCCTGCGGGGACACAG
+GATTGGGAGTGGTACAGGGATGCCCGGGAGGCGAGTGAGGAAGCCAGGCC
+ATCCTGCCACCGTCTCCCCAGCACCAAGGCTCGCAGGTTCAGCCGCCAGC
+ACAACCGCATCGTGAAGCAGGACGGCTCCAGCAGCGAGGCTGAGGACTGG
+GAGACGCCAAAGCCCTTCTACCAGCTGCTGGCCGAGAAGGCCTTGCCGCT
+GCCCCCGCACCTCCAGTGAGAGGGCGGCCCCTCGCCTCGCTCCCCTCACC
+CCTCATGGCAACCGCGGCTCTTGCTGGAAGCCAGGACCCATCGATGAACT
+TGTCCCTCCTGGGCCTCCAGCCCCTGAGAATGCAGGTCCCATGGGACTGG
+GGAGGGGGGCACTGATTAGCCCCAACCGCTGGGCACATTTGCCTGGAGCA
+CCAGAGTCACCCACAGCTGCCTTGATTCTCCCCCAGGCTTAGGAAGGAAA
+CCCAAAATGAAATGCGGGGTGTCGGAAGGTGAAGTTTACCCACCCCTCTC
+CCCTTCCCTTCCCCACCCCAGAGCCACTCGGTTGCAACCCTGTTCATGCT
+CACCTCACCCTACTCCTCCCTCTCCTGTTCTATTTTTAGACTATTTATTG
+TTTTAAATAAAATAAAGCAAGTGGAACCTTTGTTACCAGCAAGAGAGACA
+AGGGCAGGCCCTCCTGCGTCCCCCTGCTGCCCCACTGGGGTGCTCCGTCC
+ACCCTCATCTGGAGGCCTGTGGCTTGCAAGAGGCCTCAGTGCCACCCCCT
+CCCCAGCCACTCTGTGCATCTGAATGCAAACCCCTCTTCCCCTCGGGAGG
+CAGCAATGGGAAGGCCAGGTCTCGAGGTGGGCTCTGTGTTCAGCGCTGCT
+TTGGACAGACACTGGAAGGCACCCCAGACCCCTGGTGGTGGTGTAATCCG
+ATAACTTTATTTTAATTGAAAATGGAGGCATAACATGTCCTAGAAAAATA
+AAGATTTAGGATACAAAGGAGACACAGCGGCAGGGCTGCCCCCAGGGATG
+AGGGAATCTTTGGTCTGGGCCGGATAATGAGGACAAGGGCTTGAGTCGAG
+GGGAGCTGGTGAAGGAAGACCCCCGTCTCCCCACAGCTGCCCCACCCCCC
+GCCCCTGGCAGGAAATGCCACACTGGGGAGGGTCTCCAGTCTCAGGGGCG
+CGGGGCTGCCTGTCCTCCACCTTCGGATTCCAGGCAGTTGTGACAACACC
+AGCTATCGGCAGAGCTATTAATAGTGTTTCAGGGAGTGACAGGGAGAGGG
+CTCTGGGGGCTGGAAGTCCGGCCCTGGGGCAGGGTGTTCCGCTTACAGCT
+AGTACCAAGTGGAGGGGGCAGGGCCCCTGAGTCAGGACCCTGAGTCCCCC
+ACGTATATGGCAGGGCACAGCATGGGGAGGGCTGTAACAGAGAGGCCTCC
+CATCCAAAGGGGGATGGAGACCTGGACAGGAGGTGGCCGGGGATACAACC
+CCCAGCACCACCAGGGCTTGGAGAGGCCACCCAGGCAGAAGGATGTGGTG
+ACTGGGGTCTTCAGCAACCGCATTTCTGGGGCTCCCCCCTCCCATTCCTG
+TCCCTGCGTCTTCAGCACCAATGTCGGGAGAGGCCACGGGGCCACACTGG
+GTCACAGTTCCAAGGGCTCCTCCACAGGCACCGACTGGAGCTGGGTCAGA
+ACCTTGGCCTCAGCTTCCAACCCCTCGTCAACCTCACCCCCTGCGGTGGC
+CCCCAGGAGCAGCCCCTCAGGGTCGGGGTCTGGCAGCCTCAGCACGGTGT
+GGGGGGCCTGTGTCCCCAGCCCCTTTTCCGCTTCCAGCAGCCCCTCTGTT
+CCTGCGCTTAGTTCCAGCCCTGCTGACCAGACAGGCACGGCCGCGGGTGA
+CAACATCAGCCCCTCTGGTGGGGGCGCCGGGAAGTTGGGCAGGAGGCCAG
+GGGAGTCAGGGGAGAAGGGCAGGCTGGTGCTGGAGGTGGTGGCAGCGGCG
+GGGGGTGGCTGCTGTGCAGAAAGGGTGCCTAGGGCGTGAGCCTCTGGGAG
+AGCAGGGCTGGGGGCCACCGGGAGGCCTCCCTCAGGCACGGAGATGGCCG
+TCTCTGGCTTCAGTGGCAGGGCCAGGCCGGGGGCTGGCGGCAGGACCTGG
+GAGACGAGCATGCTGGTGGGGAAGGTGGCGGTGAGGATGATCTTGCCCTG
+CTGCAGGGCCACACCCGTCACGATGGGGCTGCCAGACACAGGGTTGGCCA
+GGAGGAAGTTTCCTGTGGGGAGAGAGGGACCGAGCGCAGGTGAGAGCCAG
+GAGAGCAGGCCAAGCCAGAGAGAAGTGGAGACTGTGCAGCTGGAGGGCGG
+GCGGAGGGAGCCTTGTGGTGGGCCTTGGGGCACTGGGACTTGCCAGGGAT
+GAGATGCCCTCCAGGAGCCCAGGGACAGCCCCTCCCTCTCCGAGATGACT
+GCACCCCTCCCCGGCTCTCACCTAGGCCTGAGGGAGGGAGATGGGGGTAC
+CTGGGGCAGTGGCCGAAGGCAGCTGCAGGGCAGTCACGCCCACCCCGGAG
+TTGATGAGGTGCACATTGGCAGGGCCTGCTGCAGCTGCCACCTTCACAGG
+GCTGCCTGGCCCGGCTGCCAACAGCTGCAGGGGCCCCACAGCCTGGGGCA
+GGGTCACCACCTGTGAGGTGGGTACTACCTGGGGCAGGTTCAATAGTGGG
+GAGGTGGGGCTCAGGCCCGTGGGATACCCCGGGGGTGGGGAGAGCGGTAC
+CACTTGTGGGGCAGCCACAGCAGGCACTGGCCCCGGGGGCAGAGGAAAGG
+TGGCAGCCGTCGGGGGGCCAGGCACCACTTGGGCCAGGGGCCCCAGGACC
+TCCTCTCCAAGGGCTGGTCCCGGAGCAGCCACCTGGGCCCCTTTGGTCTC
+AGGGGCCTCCGACTGAGCCTCCTCCAGCCGCACCTCCCCTGTCTGAGGGT
+CCAGGACCAGAGAGGTCTTGGTCTCGCTGGCCCCCTGAGGGCTGGGCTGC
+GGTGGAGGGGCACCCCCGCCCCCAGTGAGCAGCAGCGGGCCCAGGCTGGA
+GGCCTCGCCCAGGGCCAGGCCGTTGATGATGACGGGGCCCCCGTTGAGGA
+GCACTGCTGGGGAGCCGCTGGCTGCCAGGAAGCTCCCGTTCACCAGGATG
+GAGGAGGAAGCCGGGCAAGGCGCGGGAGGGCCGGTCCCTGCCAGGAATAT
+GGAGCCCTGGGCAGCGGCCTCGGCGGACACTGGGGCCGCCCCTCTCTCCA
+GGTCCTCAGGACTTCGGCTGGACTCGTCCTCAGTCGTGGGATTCCCATCA
+GACTCGCTGGCCGGAGAAATGGCTGTCAGCTGGGGTCCCTTAGCCTGTGG
+GGCCTCCCGCATAGCCAGCCAGCTGCTCCCCCACCTTTCCCTGGCCCAAG
+TTTCGGTGGATCATTCCAGGGGTTATGACGCCTCTCTGAGACCACTCCAA
+ACTCCAGGGCCTTTTGCAAGCCCTGCGTGGACACCACTGCAGAGAAGCGC
+TGGGGAGGGAAGAGGCCCTTGCTCTCCCCCACCTCGGCCTCGGGTCCCCA
+GAGGCTGAGCTCCCAGGTTGCCCTAAAAGTTCCTTGGTTGGGCGGAAAGC
+GGGCGAGTGGCCTGGAGAGAGGGAGCAGCAGCCGCCAGCCCAGTTCCCGG
+TGCCCTCCCCGCGGGGCGTCAGAGAAGGGAGAGGCCGGCGCTCAGGGTGG
+GAGGAGAAGGGTTTGGGTTACAGGGAAACCGGAGCTGGGAAAGGTTCACG
+TTTCACAACAAAGGCAGAAGACGGACCACGCCGTCCGGGCCCGGAGGGAG
+TGTGGGGGCGGGTGGGTAAGAGTAACGGTCAGTGAAGAAAGGGGGCTGGG
+AGGCAGCCCCTACGCGGAGTGGAGTGGCCACAGGCCCTGTCCTTTTTCCT
+CAGTCCCTCTAGTGCCCCCCGCAGTGTGATTCCCCAACACCGATGGGATT
+TGGGAAGGAGCTCGGAATGGAGCCGCTGGAAGAGGAGACGCGTGCGGGGA
+GAGGGCCCGGGCGGGTGCCTGTCCCGTCCACACTTAGTCCCCGCGCCCCG
+CGGGCGCCTGAGATTGTGAGCTGGTCCCGGGAGATGTCCGAGGACCTCGG
+CGCGCCGGCCCCAGCAGTGGGCACGGGGGAAGAGGGCTGGTGGACGGGAT
+GTCCCCGGGAGAGCTGGACTTGCGCCGCCCGAGGCCCCTCACCTCTTGCA
+GGGCGCGCCGCCTCCGGCCCCGGTCCGGTCGCGCTGTCGCCGGTTCTTGA
+ACCAGTTGCTGACCTGCGTGAGCGACAGGCCGGTGAGTGTGGCCAGGCGG
+CGCTTCTCGTCCGGCGTGGGGTAGCGGTTGCCGCGGTAGCAGGCCTTGAG
+CGCTGCGCGGGAGCGCTCCTTGAAGCAGTAGACTGTCTCCTCGCCGTCCC
+AGATGGTCTTGGGCAGCGGGAACTTCTTGCGCAGTCGATACTTGTCCACT
+GCGCCAAGCGCGCGGCCGCGGGCCCGCTCGGCCTCATGGTAGCGCGCGCG
+CAGGTAGAGGTCCTGCAGGAAGGCGTGGTGGGCGGCGGGGAAGGGGCGGC
+TCTCGAGTAGCCGGTAGAGCTCGGCGTACTCGCCCCGCTGGAAGGCCACC
+AGGGCCCGCGCGCGCAACACCGGGTCGCTGCCACGTAGGCGCTCGGCCGG
+GGGCAGTGCGCCCAGGAAGCGGCTCAAGCGGCCGGCGTGGCCCGCCTGGA
+GCAGCGCCTCGCAGACGCACGCCACCTGCTCGGGCGAGAAGCGGAGGCCC
+GTGGGCGGTTCGGAAGCGGCCTCGGGGGGCGACCCGGGGACGCCCGGGGA
+TCCCGGGCCCTCAGCTCCCGCAGCCGCTGCGCCCGCCCCGGCCCCGGCCG
+CCGCCGCCGCCTCACCCTCGGCCGCCTGCAAAGTCTGCAAGAGCTGGCGC
+GCTTCCTCCTCCTCCTCTTCGGTCGCCGCCGCCGCCGCCACCGCCTCCCC
+CCCAGCCGCCGGCCCCGCGCTCGGCTCCGCAGGCAAGGTAGCCATGTTTT
+GCAACTTTGGGAAGTTcctccctccctctcttcctccctcGGGCTTTCCC
+CAGCCTCCTCCCCCACCTGTCCCCCCTTTTCGCCCCCACTCCCCGCTCTT
+CTCGATCTTCTTTCTGGCCGACCCTGCGCCCCACGCCGGGAAGGCGAGAT
+CCAGCTCTCCACTCGGGTCTCTGTCCCCTTGTGTGTGTCCGTCCCCCTCC
+CGTCTGTCTGTGATTCTCCCTTTGTTTTCCCTCCGCCTCTGGCCGCGCTT
+TCTGCCTCCCCCCAGCGTGTGCTTCTGGCTCAGGGCCTCAGTTTCCCCAT
+CGGGACAACGCAGAAGGTAACGGGCCGTCCAGGAGGACTAAGGGCGCGAA
+GCCTCCGCCCCGAGACTGAGCTTCTGCACGCCTCCGTCTCCAGGGTCCTC
+TGCAGGCCCCCACATTCCCCATCTCGGCCTGCGCTCCGCCCCTCGGAATT
+CCCGGCTCCGCAGGGGGGGCGGGTCTGGCCGGGAGGAGGGGCGGGGAACG
+GGCTAGAAAGTTTGCAGCAACTTTTCTCGAGCTTGCGTCCCAGGAGCGGA
+TGCGCGTGGCGTGCGCAGGCGCAGTGGAAGGAGGATGGCCGCGCGCGCTG
+CCAGCCCAGCCCCCTCTTCTCGACGCTCGGTGGCACAGCTGGGCCACAGC
+TGGGCGGGGGCGGTGCCTCCGGGTGGCCCGCTCGCCCTCCTATTGGCCGG
+ACGCCAAAGCCCCGCCCCGTGGCTTTTCCTCCCCCAACCCTGATTCGGCC
+GCTTCGCATCCCGCTAGCTCCTCCCAGACCTTCGGCCGCCTCCACACGCC
+TCCGGATTGGCCCGCTGCGGAGCCTCCGGCCCACAACGCAAACCGCGGAC
+ACTGTGGAGTCCAGAGCTTTGGGCAGATGGAGGGCCTTTTATTCGCGAGG
+GTCGGGGGTGGGGGTCCTAGGTGGGGACAGACAATAAATACCGAGGAATG
+TCGGGGTCTCAGTGCATCCAAAACGTGGATTGGGGTTGTTGGGGGTCCTG
+TAGCCTGTCAGCGAGTCGGAGGACGAGGTCAATAAATATCCAAACCGCCG
+AAGCGGGCGGAGCCGGCTGGGGCTCCGAGAGCAGCGCAAGTGAGGAGGGG
+GGCGCGGGATCCCCGAAAAAGCGGGTTTGGCAAAAGCAAATTTCCCGAGT
+AAGCAGGCAGAGATCGCGCCAGACGCTCCCCAGAGCAGGGCGTCATGCAC
+AAGAAAGCTTTGCACTTTGCGAACCAACGATAGGTGGGGGTGCGTGGAGG
+ATGGAACACGGACGGCCCGGCTTGCTGCCTTCCCAGGCCTGCAGTTTGCC
+CATCCACGTCAGGGCCTCAGCCTGGCCGAAAGAAAGAAATGGTCTGTGAT
+CCCCCcagcagcagcagcagcagcagcagcagcagcagcagcagcagcag
+cagcagcagcagcagcaTTCCCGGCTACAAGGACCCTTCGAgccccgttc
+g