diff --git a/.changeset/wise-pandas-warn.md b/.changeset/wise-pandas-warn.md
new file mode 100644
index 00000000000..9a640af4ab4
--- /dev/null
+++ b/.changeset/wise-pandas-warn.md
@@ -0,0 +1,8 @@
+---
+"@cloudflare/workers-utils": patch
+"wrangler": patch
+---
+
+Warn when `CLOUDFLARE_COMPLIANCE_REGION` overrides a conflicting configured compliance region
+
+Wrangler now explains that the environment variable takes precedence and continues using its value instead of rejecting the command.
diff --git a/packages/workers-utils/src/environment-variables/misc-variables.ts b/packages/workers-utils/src/environment-variables/misc-variables.ts
index e533bff9852..be1ef3dac89 100644
--- a/packages/workers-utils/src/environment-variables/misc-variables.ts
+++ b/packages/workers-utils/src/environment-variables/misc-variables.ts
@@ -1,6 +1,4 @@
 import path from "node:path";
-import { dedent } from "ts-dedent";
-import { UserError } from "../errors";
 import { getGlobalConfigPath } from "../global-wrangler-config-path";
 import {
 	getBooleanEnvironmentVariableFactory,
@@ -101,20 +99,6 @@ export const getCloudflareComplianceRegion = (
 	complianceConfig: ComplianceConfig
 ) => {
 	const complianceRegionFromEnv = getCloudflareComplianceRegionFromEnv();
-	if (
-		complianceRegionFromEnv !== undefined &&
-		complianceConfig?.compliance_region !== undefined &&
-		complianceRegionFromEnv !== complianceConfig.compliance_region
-	) {
-		throw new UserError(
-			dedent`
-			The compliance region has been set to different values in two places:
-			 - \`CLOUDFLARE_COMPLIANCE_REGION\` environment variable: \`${complianceRegionFromEnv}\`
-			 - \`compliance_region\` configuration property: \`${complianceConfig.compliance_region}\`
-			`,
-			{ telemetryMessage: false }
-		);
-	}
 	return (
 		complianceRegionFromEnv || complianceConfig?.compliance_region || "public"
 	);
diff --git a/packages/wrangler/src/__tests__/deploy/environments.test.ts b/packages/wrangler/src/__tests__/deploy/environments.test.ts
index f049de04a07..3621a1ae6a0 100644
--- a/packages/wrangler/src/__tests__/deploy/environments.test.ts
+++ b/packages/wrangler/src/__tests__/deploy/environments.test.ts
@@ -451,19 +451,23 @@ describe("deploy", () => {
 			await runWrangler("deploy ./index.js");
 		});
 
-		it("should error if the region is set in both env var and configured, and they conflict", async ({
+		it("should warn and use the env var if it conflicts with the configured region", async ({
 			expect,
 		}) => {
 			vi.stubEnv("CLOUDFLARE_COMPLIANCE_REGION", "public");
 			writeWranglerConfig({ compliance_region: "fedramp_high" });
 			writeWorkerSource();
+			mockUploadWorkerRequest({
+				expectedBaseUrl: "api.cloudflare.com",
+			});
+			mockSubDomainRequest();
+			mockGetWorkerSubdomain({ enabled: true });
 
-			await expect(runWrangler("deploy ./index.js")).rejects
-				.toThrowErrorMatchingInlineSnapshot(`
-				[Error: The compliance region has been set to different values in two places:
-				 - \`CLOUDFLARE_COMPLIANCE_REGION\` environment variable: \`public\`
-				 - \`compliance_region\` configuration property: \`fedramp_high\`]
-			`);
+			await runWrangler("deploy ./index.js");
+
+			expect(std.warn).toContain(
+				'The compliance region was resolved to "public" from the `CLOUDFLARE_COMPLIANCE_REGION` environment variable, which takes precedence over the configured value "fedramp_high".'
+			);
 		});
 
 		it("should not error if the region is set in both env var and configured, and they are the same", async () => {
diff --git a/packages/wrangler/src/config/index.ts b/packages/wrangler/src/config/index.ts
index 72e94aea161..41c508a4f61 100644
--- a/packages/wrangler/src/config/index.ts
+++ b/packages/wrangler/src/config/index.ts
@@ -4,6 +4,7 @@ import {
 	configFileName,
 	experimental_readRawConfig,
 	FatalError,
+	getCloudflareComplianceRegion,
 	isPagesConfig,
 	normalizeAndValidateConfig,
 	UserError,
@@ -68,6 +69,25 @@ async function logWarningsWithUpgradeHint(
 	}
 }
 
+function logWarningsIfComplianceRegionIsOverridden(
+	config: Config,
+	hideWarnings: boolean | undefined
+): void {
+	const configuredRegion = config.compliance_region;
+	if (hideWarnings || configuredRegion === undefined) {
+		return;
+	}
+
+	const resolvedRegion = getCloudflareComplianceRegion(config);
+	if (resolvedRegion === configuredRegion) {
+		return;
+	}
+
+	logger.once.warn(
+		`The compliance region was resolved to "${resolvedRegion}" from the \`CLOUDFLARE_COMPLIANCE_REGION\` environment variable, which takes precedence over the configured value "${configuredRegion}".`
+	);
+}
+
 /**
  * Carries the validated `Config` alongside the
  * watcher dependency set and the normalised type-generation settings.
@@ -123,6 +143,7 @@ export async function readNewConfig(
 	);
 
 	void logWarningsWithUpgradeHint(diagnostics, options.hideWarnings);
+	logWarningsIfComplianceRegionIsOverridden(config, options.hideWarnings);
 	if (diagnostics.hasErrors()) {
 		throw new UserError(diagnostics.renderErrors(), {
 			telemetryMessage: "new-config worker validation failed",
@@ -175,6 +196,7 @@ export function readConfig(
 	);
 
 	void logWarningsWithUpgradeHint(diagnostics, options?.hideWarnings);
+	logWarningsIfComplianceRegionIsOverridden(config, options.hideWarnings);
 	if (diagnostics.hasErrors()) {
 		throw new UserError(diagnostics.renderErrors(), {
 			telemetryMessage: "config wrangler validation failed",
@@ -238,6 +260,7 @@ export function readPagesConfig(
 	);
 
 	void logWarningsWithUpgradeHint(diagnostics, options.hideWarnings);
+	logWarningsIfComplianceRegionIsOverridden(config, options.hideWarnings);
 	if (diagnostics.hasErrors()) {
 		throw new UserError(diagnostics.renderErrors(), {
 			telemetryMessage: "config pages validation failed",