diff --git a/.github/workflows/run-regression-high-performance.yml b/.github/workflows/run-regression-high-performance.yml
index 75aff3b90..7a7bce3fc 100644
--- a/.github/workflows/run-regression-high-performance.yml
+++ b/.github/workflows/run-regression-high-performance.yml
@@ -233,7 +233,7 @@ jobs:
     with:
       suite_name: aggregate_functions
       part: 1
-      timeout_minutes: 180
+      timeout_minutes: 360
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -269,7 +269,7 @@ jobs:
     with:
       suite_name: aggregate_functions
       part: 3
-      timeout_minutes: 240
+      timeout_minutes: 360
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -303,11 +303,11 @@ jobs:
     with:
       suite_name: alter
       job_name: alter_replace_partition
-      timeout_minutes: 180
+      timeout_minutes: 360
       storage_path: /replace_partition
       regression_args: '--only "/alter/replace partition/*"'
       artifact_name: alter-replace-partition-artifacts
-      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax31-cax41' || 'type-cx53-cpx52' }}
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -496,6 +496,7 @@ jobs:
       part: ${{ matrix.part }}
       timeout_minutes: 180
       storage_path: /no_ssl
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -520,6 +521,7 @@ jobs:
       storage_path: /ssl
       regression_args: '--ssl'
       artifact_name: clickhouse_keeper-ssl-artifacts
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -585,7 +587,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: disk_level_encryption
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -667,6 +669,7 @@ jobs:
     with:
       suite_name: functions
       timeout_minutes: 180
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -683,7 +686,7 @@ jobs:
     with:
       suite_name: iceberg
       part: 1
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /iceberg
       regression_args: '--only "/iceberg/iceberg engine/rest catalog/*" "/iceberg/s3 table function/*" "/iceberg/icebergS3 table function/*" "/iceberg/iceberg cache/*"'
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
@@ -703,7 +706,7 @@ jobs:
     with:
       suite_name: iceberg
       part: 2
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /iceberg 
       regression_args: '--only "/iceberg/iceberg engine/glue catalog/*" "/iceberg/iceberg table engine/*"'
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
@@ -826,7 +829,7 @@ jobs:
     with:
       suite_name: ldap/role_mapping
       job_name: ldap_role_mapping
-      timeout_minutes: 180
+      timeout_minutes: 360
       artifact_name: ldap-role_mapping-artifacts
       ref: ${{ inputs.ref }}
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax31-cax41' || 'type-cx53-cpx52' }}
@@ -844,8 +847,8 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: lightweight_delete
-      timeout_minutes: 180
-      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
+      timeout_minutes: 300
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -861,8 +864,8 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: memory
-      timeout_minutes: 180
-      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
+      timeout_minutes: 360
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -878,10 +881,10 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: parquet
-      timeout_minutes: 180
+      timeout_minutes: 300
       storage_path: /no_s3
       ref: ${{ inputs.ref }}
-      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
       flags: ${{ inputs.flags }}
@@ -921,6 +924,7 @@ jobs:
       storage_path: /aws_s3
       regression_args: '--storage aws_s3 --aws-s3-bucket {{AWS_BUCKET}} --aws-s3-region {{AWS_REGION}} --aws-s3-key-id {{AWS_KEY_ID}} --aws-s3-access-key {{AWS_ACCESS_KEY}} --only "/parquet/aws s3/*"'
       artifact_name: parquet-aws-artifacts
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -1012,7 +1016,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 1
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1030,7 +1034,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 2
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1048,7 +1052,7 @@ jobs:
     uses: ./.github/workflows/reusable-suite.yml
     with:
       suite_name: rbac
-      timeout_minutes: 180
+      timeout_minutes: 300
       part: 3
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
@@ -1291,7 +1295,7 @@ jobs:
       storage_path: /minio
       regression_args: '--storage minio'
       artifact_name: s3-minio-artifacts
-      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax31-cax41' || 'type-cx53-cpx52' }}
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -1308,6 +1312,7 @@ jobs:
     with:
       suite_name: selects
       timeout_minutes: 180
+      runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
       version: ${{ inputs.version }}
@@ -1356,7 +1361,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 1
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -1374,7 +1379,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 2
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-cpx62' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -1392,7 +1397,7 @@ jobs:
     with:
       suite_name: ssl_server
       part: 3
-      timeout_minutes: 180
+      timeout_minutes: 300
       runner_type: ${{ inputs.arch == 'arm64' && 'type-cax41' || 'type-ccx33' }}
       ref: ${{ inputs.ref }}
       package: ${{ inputs.package }}
@@ -1447,7 +1452,7 @@ jobs:
     with:
       suite_name: tiered_storage
       job_name: tiered_storage_gcs
-      timeout_minutes: 180
+      timeout_minutes: 360
       storage_path: /gcs
       regression_args: '--with-s3gcs --gcs-uri {{GCS_URI}} --gcs-key-id {{GCS_KEY_ID}} --gcs-key-secret {{GCS_KEY_SECRET}}'
       artifact_name: tiered_storage-gcs-artifacts
diff --git a/aggregate_functions/regression.py b/aggregate_functions/regression.py
index 148d2c35b..a2722f434 100755
--- a/aggregate_functions/regression.py
+++ b/aggregate_functions/regression.py
@@ -872,17 +872,33 @@ def regression(
             order_by="tuple()",
         )
 
+    with And("I increase query timeouts for sanitizer builds"):
+        if check_with_any_sanitizer(self):
+            default_query_settings = getsattr(
+                current().context, "default_query_settings", []
+            )
+            # Sanitizer builds (ASAN/TSAN/MSAN/UBSAN) are 5-10x slower; the heavy
+            # INSERTs with all data types in `populate tables with test data`
+            # can exceed the default 120s wait_for_async_insert_timeout on slower
+            # CI runners. receive/send_timeout cover network-level waits;
+            # wait_for_async_insert_timeout covers the server-side async insert
+            # flush ack which is what actually trips first under sanitizers.
+            default_query_settings.append(("receive_timeout", 900))
+            default_query_settings.append(("send_timeout", 900))
+            default_query_settings.append(("wait_for_async_insert_timeout", 900))
+            self.context.default_query_settings = default_query_settings
+
     with And("I populate tables with test data"):
         self.context.table.insert_test_data(cardinality=1, shuffle_values=False)
         self.context.table_extra_data.insert_test_data(
             cardinality=5, shuffle_values=True
         )
 
-    with And("allow higher cpu_wait_ratio "):
+    with And("allow higher cpu_wait_ratio (increased for sanitizer builds)"):
         if check_clickhouse_version(">=25.4")(self):
             allow_higher_cpu_wait_ratio(
-                min_os_cpu_wait_time_ratio_to_throw=20,
-                max_os_cpu_wait_time_ratio_to_throw=30,
+                min_os_cpu_wait_time_ratio_to_throw=50,
+                max_os_cpu_wait_time_ratio_to_throw=100,
             )
 
     with Feature("part 1"):
diff --git a/aggregate_functions/tests/rankCorr.py b/aggregate_functions/tests/rankCorr.py
index b8449400f..cc90f3efb 100644
--- a/aggregate_functions/tests/rankCorr.py
+++ b/aggregate_functions/tests/rankCorr.py
@@ -2,7 +2,7 @@
 
 from helpers.datatypes import Float64
 from helpers.tables import is_numeric, common_columns, unwrap
-from helpers.common import check_clickhouse_version, check_current_cpu
+from helpers.common import check_clickhouse_version, check_current_cpu, check_with_tsan
 from aggregate_functions.tests.steps import (
     execute_query,
     permutations_with_replacement,
@@ -68,8 +68,10 @@ def scenario(self, func="rankCorr({params})", table=None, snapshot_id=None):
 
     with Check("with group by"):
         snapshot_name_override = None
-        if "State" in self.name and "_binary" in getattr(
-            self.context, "clickhouse_path", ""
+        # TSAN produces same FP rounding as the binary build for rankCorrState.
+        if "State" in self.name and (
+            "_binary" in getattr(self.context, "clickhouse_path", "")
+            or check_with_tsan(self)
         ):
             snapshot_name_override = (
                 current().name.replace("/part 3", "") + "_binary"
diff --git a/alter/regression.py b/alter/regression.py
index 297fa2cdd..1795646b4 100755
--- a/alter/regression.py
+++ b/alter/regression.py
@@ -34,6 +34,29 @@ def argparser(parser):
 
 
 xfails = {
+    # Data corruption bugs exposed by sanitizer builds
+    "/alter/attach partition/*": [
+        (
+            Fail,
+            "UNKNOWN_CODEC data corruption with sanitizers - needs investigation",
+            check_with_any_sanitizer,
+        )
+    ],
+    "/alter/replace partition/*": [
+        (
+            Fail,
+            "UNKNOWN_CODEC data corruption with sanitizers - needs investigation",
+            check_with_any_sanitizer,
+        )
+    ],
+    # Merge part UINT32_MAX overflow bug
+    "/alter/attach partition/*/optimize table * final/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/issues/69001 - Merge part UINT32_MAX overflow",
+            check_with_any_sanitizer,
+        )
+    ],
     "/alter/replace partition/concurrent merges and mutations/mutations on unrelated partition": [
         (
             Fail,
diff --git a/base_58/regression.py b/base_58/regression.py
index 14f85fb5c..bcc0bedb8 100755
--- a/base_58/regression.py
+++ b/base_58/regression.py
@@ -10,11 +10,25 @@
 
 from helpers.cluster import create_cluster
 from helpers.argparser import argparser, CaptureClusterArgs
-from helpers.common import check_clickhouse_version, experimental_analyzer
+from helpers.common import check_clickhouse_version, experimental_analyzer, check_with_any_sanitizer
 
 pr_70846 = "https://github.com/ClickHouse/ClickHouse/pull/70846"
 
 xfails = {
+    # Memory-delta assertions incompatible with sanitizer allocators
+    # (b58_decode_memory_usage > 0 fails under ASAN/MSAN).
+    "/base58/memory usage/*": [
+        (
+            Fail,
+            "Memory-delta assertions incompatible with sanitizer allocators",
+            check_with_any_sanitizer,
+        ),
+        (
+            Error,
+            "Memory-delta assertions incompatible with sanitizer allocators",
+            check_with_any_sanitizer,
+        ),
+    ],
     "alias input/alias instead of table and column": [(Fail, "not implemented")],
     "/base58/unsupported types constant/Nullable（FixedString（3））/*": [
         (
diff --git a/helpers/cluster.py b/helpers/cluster.py
index 699492a82..07bfe2e24 100755
--- a/helpers/cluster.py
+++ b/helpers/cluster.py
@@ -630,7 +630,7 @@ def enable_thread_fuzzer(self):
                 "export THREAD_FUZZER_pthread_mutex_unlock_AFTER_SLEEP_TIME_US=10000"
             )
 
-    def wait_clickhouse_healthy(self, timeout=90, check_version=True, initial_delay=0):
+    def wait_clickhouse_healthy(self, timeout=600, check_version=True, initial_delay=0):
         with By(f"waiting until ClickHouse server on {self.name} is healthy"):
             for attempt in retries(
                 timeout=timeout, delay=5, initial_delay=initial_delay
@@ -782,7 +782,7 @@ def stop_clickhouse(self, timeout=300, safe=True, signal="TERM"):
 
     def start_clickhouse(
         self,
-        timeout=60,
+        timeout=600,
         wait_healthy=True,
         user=None,
         thread_fuzzer=False,
@@ -843,9 +843,7 @@ def start_clickhouse(
                         timeout=timeout, check_version=check_version, initial_delay=2
                     )
 
-    def restart_clickhouse(
-        self, timeout=300, safe=True, wait_healthy=True, retry_count=5, user=None
-    ):
+    def restart_clickhouse(self, timeout=600, safe=True, wait_healthy=True, retry_count=5, user=None):
         """Restart ClickHouse server."""
         self.stop_clickhouse(timeout=timeout, safe=safe)
 
diff --git a/helpers/common.py b/helpers/common.py
index 1da0e3421..a6f1b5752 100644
--- a/helpers/common.py
+++ b/helpers/common.py
@@ -56,7 +56,10 @@ def check(test):
 def check_with_ubsan(test):
     """Check if the build is with undefined behavior sanitizer (ubsan)."""
     if hasattr(test.context, "build_options"):
-        if "ubsan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "ubsan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -65,7 +68,10 @@ def check_with_ubsan(test):
 def check_with_tsan(test):
     """Check if the build is with thread sanitizer (tsan)."""
     if hasattr(test.context, "build_options"):
-        if "tsan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "tsan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -74,7 +80,10 @@ def check_with_tsan(test):
 def check_with_asan(test):
     """Check if the build is with address sanitizer (asan)."""
     if hasattr(test.context, "build_options"):
-        if "asan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "asan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -83,7 +92,10 @@ def check_with_asan(test):
 def check_with_msan(test):
     """Check if the build is with memory sanitizer (msan)."""
     if hasattr(test.context, "build_options"):
-        if "msan" in test.context.build_options.values():
+        if any(
+            node_build_options.get("sanitizer") == "msan"
+            for node_build_options in test.context.build_options.values()
+        ):
             return True
 
     return False
@@ -243,7 +255,9 @@ def check_with_any_sanitizer(test):
     sanitizers = ["tsan", "asan", "ubsan", "msan"]
     if hasattr(test.context, "build_options"):
         return any(
-            sanitizer in test.context.build_options.values() for sanitizer in sanitizers
+            node_build_options.get("sanitizer") == sanitizer
+            for node_build_options in test.context.build_options.values()
+            for sanitizer in sanitizers
         )
     return False
 
@@ -256,7 +270,8 @@ def check_several_sanitizers_in_binary_link(
     def check(test):
         if hasattr(test.context, "build_options"):
             return any(
-                sanitizer in test.context.build_options.values()
+                node_build_options.get("sanitizer") == sanitizer
+                for node_build_options in test.context.build_options.values()
                 for sanitizer in sanitizers
             )
         return False
diff --git a/iceberg/regression.py b/iceberg/regression.py
index 74c17699c..f63b16c45 100755
--- a/iceberg/regression.py
+++ b/iceberg/regression.py
@@ -19,11 +19,34 @@
     check_is_altinity_build,
     experimental_analyzer,
     check_if_antalya_build,
+    check_with_any_sanitizer,
     check_if_antalya_post_26_3_10_20001,
 )
 
 
 xfails = {
+    # Server crashes with "Metadata is not initialized" during schema evolution with sanitizers
+    "/iceberg/iceberg engine/*/schema evolution/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/issues/86024 - Iceberg metadata initialization bug with sanitizers",
+            check_with_any_sanitizer,
+        )
+    ],
+    # Logical error 'prewhere_info' on Iceberg row policies without PREWHERE (sanitizer-only chassert).
+    # Fixed upstream in CH#100361; not backported to stable-26.3.
+    "/iceberg/iceberg table engine/feature/row policies/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/pull/100361 - not backported to stable-26.3",
+            check_with_any_sanitizer,
+        ),
+        (
+            Error,
+            "https://github.com/ClickHouse/ClickHouse/pull/100361 - not backported to stable-26.3",
+            check_with_any_sanitizer,
+        ),
+    ],
     "/iceberg/export partition/*/manifest integrity/value_counts across data files sum to source row count": [
         (
             Fail,
@@ -307,6 +330,11 @@
 }
 
 ffails = {
+    "/iceberg/iceberg engine/*": (
+        Skip,
+        "Iceberg tests unstable with sanitizer builds (server startup issues)",
+        check_with_any_sanitizer,
+    ),
     "/iceberg/iceberg engine": (
         Skip,
         "Iceberg engine was introduced in 24.12",
diff --git a/kerberos/regression.py b/kerberos/regression.py
index 01a2a55a4..ea767aeb7 100755
--- a/kerberos/regression.py
+++ b/kerberos/regression.py
@@ -8,13 +8,28 @@
 
 from helpers.cluster import create_cluster
 from helpers.argparser import argparser, CaptureClusterArgs
-from helpers.common import check_clickhouse_version, experimental_analyzer
+from helpers.common import check_clickhouse_version, experimental_analyzer, check_with_msan
 from kerberos.requirements.requirements import *
 
 xfails = {
     "config/principal and realm specified/:": [
         (Fail, "https://github.com/ClickHouse/ClickHouse/issues/26197")
     ],
+    # MSAN aborts on every kerberos request: bufferToString strips trailing
+    # NUL bytes from opaque AP-REP tokens, causing krb5 ASN.1 decoder to read
+    # uninitialized memory. Fixed upstream in CH#103114, not backported to stable-26.3.
+    "/kerberos/*": [
+        (
+            Fail,
+            "https://github.com/ClickHouse/ClickHouse/pull/103114 - not backported to stable-26.3",
+            check_with_msan,
+        ),
+        (
+            Error,
+            "https://github.com/ClickHouse/ClickHouse/pull/103114 - not backported to stable-26.3",
+            check_with_msan,
+        ),
+    ],
 }
 
 ffails = {
diff --git a/ontime_benchmark/tests/benchmark.py b/ontime_benchmark/tests/benchmark.py
index b777d8fdf..ee8b080be 100644
--- a/ontime_benchmark/tests/benchmark.py
+++ b/ontime_benchmark/tests/benchmark.py
@@ -14,9 +14,12 @@ def insert_ontime_data(self, from_year, to_year, table_name, node=None):
     if node is None:
         node = self.context.node
 
+    # Sanitizer builds are 3-4x slower; bump ingest timeout accordingly.
+    query_timeout = 3600 if check_with_any_sanitizer(self) else 1200
+
     node.query(
         f"INSERT INTO {table_name} SELECT * FROM ontime_data WHERE Year BETWEEN {from_year} AND {to_year}",
-        timeout=1200,
+        timeout=query_timeout,
     )
 
 
@@ -27,6 +30,11 @@ def fetch_ontime_data(self, from_year, to_year, node=None):
     if node is None:
         node = self.context.node
 
+    # Sanitizer builds are 3-4x slower; bump CSV.gz ingest timeouts accordingly.
+    sanitized = check_with_any_sanitizer(self)
+    query_timeout = 3600 if sanitized else 1200
+    receive_timeout = 1800 if sanitized else 600
+
     with Given("I create a table to store ontime data locally"):
         create_ontime_table(
             table_name="ontime_data",
@@ -45,10 +53,10 @@ def fetch_ontime_data(self, from_year, to_year, node=None):
         node.query(
             f"INSERT INTO ontime_data "
             f"SELECT * FROM s3('https://clickhouse-public-datasets.s3.amazonaws.com/ontime/csv_by_year/{{{from_year}..{to_year}}}.csv.gz', CSVWithNames) "
-            "SETTINGS receive_timeout=600, "
+            f"SETTINGS receive_timeout={receive_timeout}, "
             "max_insert_threads=10, "  # This affects memory more than it affects performance
             "max_memory_usage=29500000000;",  # Runners have about this much available memory
-            timeout=1200,
+            timeout=query_timeout,
         )
 
 
diff --git a/parquet/regression.py b/parquet/regression.py
index ec0773570..d492407bb 100755
--- a/parquet/regression.py
+++ b/parquet/regression.py
@@ -23,6 +23,7 @@
     allow_higher_cpu_wait_ratio,
     check_if_not_antalya_build,
     check_if_antalya_build,
+    check_with_any_sanitizer,
 )
 from parquet.tests.common import start_minio, parquet_test_columns
 
@@ -501,6 +502,18 @@ def regression(
                 max_os_cpu_wait_time_ratio_to_throw=20,
             )
 
+    with And("I increase query timeouts for sanitizer builds"):
+        if check_with_any_sanitizer(self):
+            default_query_settings = getsattr(
+                current().context, "default_query_settings", []
+            )
+            # Heavy INSERTs exceed default 120s wait_for_async_insert_timeout on
+            # slow sanitizer runners (observed in parquet under MSAN/TSAN).
+            default_query_settings.append(("receive_timeout", 900))
+            default_query_settings.append(("send_timeout", 900))
+            default_query_settings.append(("wait_for_async_insert_timeout", 900))
+            self.context.default_query_settings = default_query_settings
+
     with And("I have a Parquet table definition"):
         columns = (
             cluster.node("clickhouse1")
diff --git a/rbac/regression.py b/rbac/regression.py
index e87303c1e..910da864f 100755
--- a/rbac/regression.py
+++ b/rbac/regression.py
@@ -9,7 +9,7 @@
 
 from helpers.cluster import create_cluster
 from helpers.argparser import argparser, CaptureClusterArgs
-from helpers.common import check_clickhouse_version, experimental_analyzer
+from helpers.common import check_clickhouse_version, experimental_analyzer, check_with_any_sanitizer
 from rbac.requirements import SRS_006_ClickHouse_Role_Based_Access_Control
 from rbac.helper.common import add_rbac_config_file
 
@@ -257,8 +257,8 @@
     ),
     "/rbac/part 1/privileges/system drop cache/compiled expression cache*": (
         Skip,
-        "Not supportted in ARM builds",
-        (lambda test: platform.machine() == "aarch64"),
+        "JIT compilation disabled in ARM and sanitizer builds",
+        (lambda test: platform.machine() == "aarch64" or check_with_any_sanitizer(test)),
     ),
     "rbac/part 1/privileges/:/table_type='ReplicatedReplacingMergeTree-sharded_cluster": (
         Skip,
diff --git a/s3/tests/common.py b/s3/tests/common.py
index c62cad9f3..d11f6f205 100644
--- a/s3/tests/common.py
+++ b/s3/tests/common.py
@@ -33,6 +33,10 @@ def add_config(
     if nodes is None:
         nodes = [cluster.node(node) for node in cluster.nodes["clickhouse"]]
 
+    # Sanitizer builds restart 3-4x slower; bump default config-reload timeout.
+    if check_with_any_sanitizer(current()) and timeout < 300:
+        timeout = 300
+
     def check_preprocessed_config_is_updated(after_removal=False):
         """Check that preprocessed config is updated."""
         started = time.time()
@@ -459,7 +463,7 @@ def remote_host_filter_config(
         config = create_remote_host_filter_config_content(
             urls, config_d_dir, config_file
         )
-    return add_config(config, restart=restart)
+    return add_config(config, timeout=timeout, restart=restart)
 
 
 def create_s3_max_redirects_config_content(
diff --git a/settings/regression.py b/settings/regression.py
index dd048cedf..3d4ce11cf 100755
--- a/settings/regression.py
+++ b/settings/regression.py
@@ -10,9 +10,29 @@
     CaptureClusterArgs,
 )
 
-from helpers.common import check_clickhouse_version, check_if_head, check_if_latest
+from helpers.common import (
+    check_clickhouse_version,
+    check_if_head,
+    check_if_latest,
+    check_with_any_sanitizer,
+)
 
 xfails = {
+    # Profiler settings have different defaults in sanitizer builds (profilers disabled)
+    "/settings/default values/query_profiler_cpu_time_period_ns": [
+        (
+            Fail,
+            "Profilers are disabled in sanitizer builds",
+            check_with_any_sanitizer,
+        )
+    ],
+    "/settings/default values/query_profiler_real_time_period_ns": [
+        (
+            Fail,
+            "Profilers are disabled in sanitizer builds",
+            check_with_any_sanitizer,
+        )
+    ],
     "/settings/default values/parallel_replicas_mark_segment_size": [
         (
             Fail,